Protocol · administration
The Nerve Honey Protocol: Dose, Timing and a 90-Day Log
Take two Nerve Honey capsules once a day with 8 oz of water, starting in the evening at home because three of the herbs can cause drowsiness, and judge it with a daily 0 to 10 symptom log before the 60-day refund window closes.
Updated November 6, 2026Checked against the printed label
The label serving, exactly
Two vegetable capsules once a day with 8 oz (about 240 mL) of water. A bottle holds 60 capsules, so one bottle lasts 30 days. The label sets no time of day, no cycling schedule and no higher dose for stronger symptoms, and the calculator below keeps it that way.
Timing
- First week: evenings, at home. Three of the five herbs can cause drowsiness; passionflower's best-known side effects are sleepiness and dizziness[1]. See how you react before you take a dose ahead of driving.
- Space it from medicines. Mucilage from marshmallow root can slow absorption of other medicines swallowed at the same time, so keep at least an hour between them[2].
- With or without food. The label does not say. If the capsules upset your stomach, take them after a meal.
- Same time daily. A fixed time makes the symptom log comparable from day to day.
A 90-day log that gives you a real answer
Pain researchers score symptoms on an 11-point scale and count a fall of about two points, or 30 percent, as clinically important[3]. Use the same yardstick on yourself, and compare weekly averages rather than single good or bad days.
| Week | Log daily (0 to 10) | Decision |
|---|---|---|
| 0 (before capsule 1) | Burning, tingling, numbness, sleep quality | Set your baseline average |
| 1 to 2 | Same four scores plus any drowsiness | Stop if rash, jaundice or heavy sedation |
| 3 to 6 | Same scores; compare 7-day averages | Day 45: keep, or start the refund |
| 7 to 13 | Same scores | Continue only if the drop holds |
Who should not start without medical advice
- Pregnant or nursing: passionflower is not advised in pregnancy[1], and there are no lactation data for marshmallow root[4]. The label excludes anyone under 18.
- Liver disease, heavy drinking or a past drug-induced liver reaction, because of corydalis[5].
- Surgery in the next two weeks: stop calming herbs ahead of anaesthesia and tell your surgeon.
- Numbness that is new, one-sided, spreading fast or paired with weakness: that needs a prompt medical review, not a supplement trial[6].
Interaction check
| If you take | Why it matters | What to do |
|---|---|---|
| Sleep aids, benzodiazepines, z-drugs | Passionflower, poppy and corydalis add drowsiness | Ask your prescriber before combining |
| Opioids, gabapentin, pregabalin | Stacked sedation and slowed breathing risk | Pharmacist review first; never start both the same week |
| Antidepressants (SSRIs, SNRIs, TCAs) | Added sedation; few interaction studies exist | Pharmacist review |
| Any daily medicine | Marshmallow mucilage can delay absorption | Separate by at least an hour |
| Liver-processed drugs, or any liver condition | Corydalis liver-injury signal | Doctor approval and baseline liver tests |
| Alcohol | Drowsiness adds up | Avoid on dosing days, at least at first |
When to stop at once
Stop and contact a clinician for yellowing skin or eyes, dark urine, pale stools or pain under the right ribs (possible liver injury), for a rash or swelling, for heavy daytime sedation or for a racing or irregular heartbeat, which has been reported with passionflower[7]. Report serious reactions to the FDA's MedWatch program[8].
Sources
- 1National Center for Complementary and Integrative Health. Passionflower.
- 2European Medicines Agency, Committee on Herbal Medicinal Products. Althaeae radix (marshmallow root): herbal medicine overview and monograph.
- 3Farrar JT, Young JP Jr, LaMoreaux L, Werth JL, Poole MR. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain. 2001;94(2):149-158.
- 4Drugs and Lactation Database (LactMed). Marshmallow. Bethesda (MD): National Library of Medicine; 2006-.
- 5Guo L, Lin L, Ling J, et al. A new discovery: Corydalis yanhusuo causes idiosyncratic hepatotoxicity and its potential mechanisms. Biomed Chromatogr. 2025;39:e70093.
- 6National Institute of Neurological Disorders and Stroke. Peripheral Neuropathy.
- 7Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol. 2000;38(1):63-66.
- 8U.S. Food and Drug Administration. MedWatch: The FDA Safety Information and Adverse Event Reporting Program.